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Breakthroughs and More

LUNG CANCER PUBLICATIONS

The N2 paradox: similar outcomes of pre- and postoperatively identified single-zone N2a positive non-small-cell lung cancer

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Synopsis: This 2014 article in the European Journal of Cardio-Thoracic Surgery delves into the management of NSCLC that has spread to nearby lymph nodes (N2 disease). The study examines the so-called "N2 paradox," where unexpected N2 disease found during surgery is often considered to have a better prognosis than N2 disease identified preoperatively. The authors' research suggests that with modern staging techniques, the outcomes for intentionally resected, preoperatively identified single-zone N2a disease are comparable to those for unexpectedly discovered N2 disease. This finding supports a more proactive surgical approach in selected patients with limited N2 disease.

Lung cancer surgery in the breathless patient — the benefits of avoiding the gold standard

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Synopsis: This pivotal 2010 study, published in the European Journal of Cardio-Thoracic Surgery, investigates the outcomes of lung cancer resection in patients with severe chronic obstructive pulmonary disease (COPD). The research compares a tailored approach, combining video-assisted thoracoscopic surgery (VATS) lobectomy and anatomical segmentectomy, with the traditional open lobectomy. The findings suggest that for breathless patients, a tailored, less invasive approach is associated with significantly better long-term survival and shorter hospital stays, challenging the "gold standard" of open surgery for this high-risk group.

Is the initial feasibility of lobectomy for stage I non-small cell lung cancer in severe heterogeneous emphysema justified by long-term survival?

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Synopsis: Published in the journal Thorax in 2007, this study investigates the long-term survival of patients with severe emphysema who undergo lobectomy for stage I NSCLC. While the surgical feasibility of this procedure in high-risk patients was known, this research questioned whether it was justified by long-term outcomes. The study found that while long-term survival in this group is limited by physiological factors rather than cancer recurrence, the outcomes are still better than with other treatment modalities. This supports offering lobectomy to carefully selected patients with severe emphysema.

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Feel free to get in touch with me if you’d like to discuss any of my published works.

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